There are several types of antidepressants that cause weight loss. Most of them have a chemical make-up that is very similar to the neurotransmitter serotonin, which is primarily responsible for regulating mood and appetite. Although the Food and Drug Administration (FDA) has not approved most of these drugs, they are widely available. Antidepressants, including tricyclics and selective serotonin reuptake inhibitors (SSRIs), are commonly used to treat depression, and in most cases they do a good job of treating the symptoms of depression and anxiety. They are also used to treat obsessive-compulsive disorders, as well as bipolar disorder and bi-polar disorder. In some cases, antidepressants may even be beneficial in weight control.

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However, some antidepressants can cause significant weight gain. Some antidepressants promote weight gain by reducing appetite, which is an undesirable side effect for many people. Because they increase the rate that the body spends burning energy, these drugs add to the amount of calories that are consumed by the body, resulting in excess weight gain. Some antidepressants, such as Anafranil (clomipramine), are designed to reduce serotonin activity in the brain, which may account for the reason why some people gain weight when taking these drugs.

SSRIs are relatively new in the pharmaceutical world, and they have had much less success than other antidepressants in terms of weight gain prevention. The reason for this is that these drugs increase the rate that serotonin is released from the brain, and it takes a longer period of time for these compounds to reach the brain than most other neurotransmitters. Although SSRIs have been shown to be effective in helping people with depression, weight gain appears to be the result of long-term use of these medications. Another common SSRI that causes weight gain is fluoxetine.

Antidepressants that cause weight loss include paroxetine, an antidepressant that is usually taken to treat obsessive-compulsive disorder. Paroxetine also causes an increase in the amount of melanin in the body, which is the reason for its propensity to give people a lighter complexion. This medication is most often prescribed to pregnant women who breastfeed. Many antidepressants that cause weight loss also contain bupropion.

Pregnant women, breastfeeding mothers, and persons taking medication for depression or anxiety need to be careful about how they react to medications. This is because even though a patient may experience some relief from depression or anxiety, these medications can still cause significant weight gain. If the healthcare provider notices an increase in weight, it is important to discuss this with the patient. A healthcare provider may choose to switch these patients to another antidepressant that causes fewer side effects. Also, if a person experiences severe side effects, they should contact a physician immediately.

There are a number of reasons why some individuals gain weight. Some of these reasons are related to diet, but other reasons relate to medication and obesity. If a patient is dealing with depression, they should be sure to discuss any thoughts or issues they have with their primary care physician. In many cases, a healthcare provider will be able to change the way a patient takes their medication and stop them from gaining an excessive amount of weight. Once a patient is treated for depression, they should always discuss weight-loss options with their healthcare provider.